Non-equilibrium atmospheric pressure asymmetric dielectric barrier discharge for transdermal drug delivery: live pig model
نویسنده
چکیده
We will report on crosslinking of ceramides molecules in the stratum corneum of a live pig by non-equilibrium atmospheric pressure asymmetric dielectric barrier discharge treatment. This crosslinking leads to formation of temporary pores in the skin, leading to increased permeability of the skin which we have validated with vitamin D.
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Transdermal drug delivery (TDD) is a non-invasive, topical administration method for therapeutic agents. Transdermal delivery also has advantages including providing release for long periods of time, improving patient compliance, and generally being inexpensive. Despite these advantages, the use of TDD has been limited by innate barrier functions of the skin. Only small (<500 Da), lipophilic mo...
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